Biographical Details
Reut holds a B.Sc. in Computer Science and Life Sciences from Tel Aviv University, and an M.Sc. in Bioinformatics from the Weizmann Institute of Science in Israel. During her PhD at the Weizmann Institute, Reut started to integrate molecular and computational biology, and has continued with this combination ever since. In 2009, Reut moved to MIT for her postdoctoral fellowship, where she studied protein homeostasis-related translation and splicing regulation, under the joint mentorship of Prof. Chris Burge and the late Prof. Susan Lindquist. Reut then became a faculty member at the Technion in the Rappaport Faculty of Medicine at the end of 2014, where she is currently an Associate Professor. She is also a member of the Rappaport Family Institute for Research in the Medical Sciences and the Prince Center for Neurodegenerative Disorders of the Brain. Reut has won several awards, including the Feruccio Ritossa Award for 2023 by the Cell Stress Society International, in recognition of her pathbreaking studies of the functions and malfunctions of proteostasis networks in aging and neurodegeneration.
Research Interests
Protein quality control networks play a crucial role in the cellular maintenance of protein homeostasis. Using a systems biology approach, combining high-throughput methodologies, molecular biology and computational biology, the Shalgi lab explores protein homeostasis regulatory networks in mammalian cells. The lab studies transcriptional regulation, translational regulation and network function, how they are integrated to achieve protein homeostasis under challenging environments, and how they fail in neurodegenerative diseases. Specifically, the lab seeks to understand both basic mechanisms underlying neurodegeneration, with a special focus on ALS, as well as how we can boost our cells’ capacity to combat these devastating diseases. By generating large scale datasets and applying computational biology tools, the Shalgi lab has unraveled novel principles underlying proteostasis regulation. The Shalgi lab strives to link multi-level regulation to function, with the overarching goal of gaining a deep understanding of how mammalian systems are well adapted to maintaining protein homeostasis, and why they fail in neurodegeneration.
Select Publications
Akaree, N., Secco, V., Levy-Adam, F., Younis, A., Carra, S., & Shalgi, R. (2025, Jan 5). Regulation of physiological and pathological condensates by molecular chaperones. FEBS J. https://doi.org/10.1111/febs.17390
Hadar, S., Meller, A., Saida, N., & Shalgi, R. (2022, Dec 22). Stress-induced transcriptional readthrough into neighboring genes is linked to intron retention. iScience, 25(12), 105543. https://doi.org/10.1016/j.isci.2022.105543
Rozales, K., Younis, A., Saida, N., Meller, A., Goldman, H., Kellerman, L., Heinrich, R., Berlin, S., & Shalgi, R. (2022, Jan 26). Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens. Nat Commun, 13(1), 516. https://doi.org/10.1038/s41467-022-27982-w
Sabath, N., Levy-Adam, F., Younis, A., Rozales, K., Meller, A., Hadar, S., Soueid-Baumgarten, S., & Shalgi, R. (2020, Dec 15). Cellular proteostasis decline in human senescence. Proc Natl Acad Sci U S A, 117(50), 31902-31913. https://doi.org/10.1073/pnas.2018138117